activated intermediate

By Targets:	ADC Cytotoxin (1) Apoptosis (1) EGFR (1) Endogenous Metabolite (5) Interleukin Related (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (3) TRP Channel (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113492

5(S)15(S)-DiHETE	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
5(S)15(S)-DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC₅₀ of 1.3 μM. 5(S)15(S)-DiHETE enhances the rate of either LXA4 or LXB4 biosynthesis .

HY-13519

TRAM-34 10+ Cited Publications	Potassium Channel	Neurological Disease
TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K ⁺ channel (IKCa1) (K_d=20 nM).

HY-400687

TAM558 intermediate-1	Others	Cancer
TAM558 intermediate-1 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

HY-400688

TAM558 intermediate-2	Others	Cancer
TAM558 intermediate-24 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

HY-400689

TAM558 intermediate-3	Others	Cancer
TAM558 intermediate-34 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

HY-400690

TAM558 intermediate-4	Others	Cancer
TAM558 intermediate-4 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

HY-48564

TAM558 intermediate-5	ADC Cytotoxin	Cancer
TAM558 intermediate-54 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

HY-78869

Mutated EGFR-IN-1 Osimertinib analog	EGFR	Cancer
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

HY-125665

Pheophorbide A	Apoptosis	Cardiovascular Disease Cancer
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research .

HY-103308

TRAM-39	Potassium Channel	Neurological Disease
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IK_Ca) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective *small conductance Ca ²⁺-activated* K ⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3**-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca ²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺), and does not affect the Ca ²⁺-activated K ⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively) .

HY-126585

SAICAR 1 Publications Verification	Endogenous Metabolite	Cancer
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-P99752

Nemvaleukin alfa ALKS 4230; RDB-1450	Interleukin Related	Inflammation/Immunology Cancer
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer .

HY-126585S

SAICAR-d1	Endogenous Metabolite	Metabolic Disease
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

HY-113037

Farnesyl pyrophosphate Farnesyl diphosphate	TRP Channel Endogenous Metabolite	Neurological Disease
Farnesyl pyrophosphate (Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-113037C

Farnesyl Pyrophosphate ammonium Farnesyl diphosphate ammonium	TRP Channel Endogenous Metabolite	Neurological Disease
Farnesyl Pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-141581

Lyso-PAF C-18	Platelet-activating Factor Receptor (PAFR) Endogenous Metabolite	Cardiovascular Disease
Lyso-PAF C-18 is an intermediate for the synthesis of C18-PAF (HY-130345). It has an easily substituted "Lyso-PAF" structure and is easy to purify and has high yield. C18-PAF is a ligand for platelet-activating factor and PAF G protein-coupled receptor (PAFR) and has renovasodilator properties and antihypertensive lipid properties .

Cat. No.	Product Name	Target	Research Area

HY-P99752

Nemvaleukin alfa ALKS 4230; RDB-1450	Interleukin Related	Inflammation/Immunology Cancer
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125665

Pheophorbide A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Apoptosis
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research .

HY-126585

SAICAR 1 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-113037C

Farnesyl Pyrophosphate ammonium Farnesyl diphosphate ammonium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
Farnesyl Pyrophosphate ammonium salt, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate ammonium salt is a TRPM2 (TRP Channel) agonist, and activates TRPM2 opening for ion influx. Farnesyl pyrophosphate ammonium salt is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-113037

Farnesyl pyrophosphate Farnesyl diphosphate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
Farnesyl pyrophosphate (Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-141581

Lyso-PAF C-18	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Platelet-activating Factor Receptor (PAFR) Endogenous Metabolite
Lyso-PAF C-18 is an intermediate for the synthesis of C18-PAF (HY-130345). It has an easily substituted "Lyso-PAF" structure and is easy to purify and has high yield. C18-PAF is a ligand for platelet-activating factor and PAF G protein-coupled receptor (PAFR) and has renovasodilator properties and antihypertensive lipid properties .

Cat. No.	Compare	Product Name	Species	Source

HY-P702350

	KCNN4 Protein, Human (Cell-Free, His) intermediate conductance calcium-activated potassium channel protein 4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel	Human	E. coli Cell-free
	KCNN4 is a voltage-dependent potassium channel that is activated by intracellular calcium, leading to membrane hyperpolarization and subsequent calcium influx. This channel is critical for the reactivation of naive T cells, helping to maximize calcium influx and promote T cell proliferation. KCNN4 Protein, Human (Cell-Free, His) is the recombinant human-derived KCNN4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNN4 Protein, Human (Cell-Free, His) is 427 a.a., with molecular weight of 59.1 kDa.


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HY-126585S

SAICAR-d1
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

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activated intermediate

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